Fat-dissolving Injections

in Newcastle and the North East

Since the 1980s non-surgical fat reduction via injectable methods have been the subject of vast amounts of research. Initially, these methods were enthusiastically received by the medical community but in the following years, popularity waned as unwanted side effects and a lack of controlled studies affected confidence in the method. In recent years new formulations, usually based on deoxycholic acid have led to an upswing in demand. Desobody/Desoface, one such method used for the reduction of submental fat was approved by US Food and Drug Administration which was something of a breakthrough for the technique.

Here is an overview of the history of fat-dissolving agents, what different options are available and what the treatment entails.

Fat-dissolving agents

Sodium deoxycholate

Sodium deoxycholate (SDC) is a type of secondary bile acid whose role in bile is to emulsify fat and ease digestion. SDC also behaves as detergent which means it disrupts the cellular membrane. This process causes the cell membrane to collapse into mixed micelles of phospholipids and detergent molecules. The specific nature of this detergent activity has been hard to track which has in some cases, when used as an aqueous solution through mesotherapy, has resulted in a number of cases of skin necrosis.

Following further study it was determined that mature adipocytes proved to be more resistant to detergent-induced cellular lysis than other cell types which in turn led to a number of safety concerns regarding the use of this type of substance in the fat compartment. Research also discovered that SDC is more effective when a lower protein content is found in the cell, which is the case with adipocytes as they have less than 5% protein content.

 Desobody is used for a treatment called injection lipolysis.

Lipolysis means fat-dissolving and that is what the injection of Desobody into targeted areas will do over a course of treatments. The active ingredient is called sodium deoxycholate (deoxycholic acid) which is a special medical detergent which breaks down fat cells. It has a concentration of 1.25% sodium deoxycholate in Desobody.

Desoface is another product which is a lower concentration of 0.5% sodium deoxycholate for treating double chins.


Phosphatidylcholine is the main phospholipid present in the human body accounting for 40-50% of the cell membrane. PC is integral to the make-up of cell membranes as it provides the main structural support to the cell.  It is also a natural emulsifier due to its lipophilic and hydrophilic properties.


Uses, side-effects, and contraindications

Fat-dissolving injections are not a weight-loss treatment and a patient should be fully aware of this before considering treatment.   Instead, this form of intervention is used to reduce and in some cases eliminate localised fat deposits within the body.  These areas often manifest as areas of the skin that remain fatty despite the patient being of normal weight, regularly exercising and maintaining a balanced, healthy diet.  The beauty of fat-dissolving injections is that they can be used almost anywhere upon the body, with common areas being back rolls, double chins and saddle bags. It can also be used as a follow-up treatment after undergoing liposuction or similar fat-reducing procedures to remove and lumps of adipose tissue created by the initial procedure.

Fat-dissolving injections can also be used to treat lipomas without scarring occurring, particularly in cases of multiple lipomatosis. It should be noted, however, that whilst these treatments are successful they can not guarantee against the recurrence of the condition.

Contraindications for these treatments are broadly similar to all forms of cosmetic treatments i.e. pregnancy, lactation, autoimmune diseases etc.  The thickness of the skin is also an important factor to consider, with patients with less than 1.5cm of thickness being unsuitable due to the increased risks of side-effects.  It also bears repeating that obesity is, alone, not an appropriate reason for a course of treatment to begin. Instead, such patients would need to also commit to a healthy diet and regular exercise to deal with weight loss. This is not to say that the treatment should be outright ignored and in fact when combined with other forms of weight loss can work to speed up the process of losing weight and act as a great motivator.


Fat Loss Injections Treatment

The initial method used to administer fat-dissolving injections, as previously discussed, was mesotherapy, and this method is still used to this day. This process consists of multiple subdermal injections of small amounts of substance (Initially these injections were also intradermally but now will always be subdermal.)

More recently the preferred method of administering the SDC, particularly desobody/desoface, has been through a technique called intralipotherapy.  Whereas mesotherapy required multiple injection sites to be used this new technique instead only requires two or three such sites. Intralipotherapy also allows the adipocytlytic agent to be released directly into the fatty tissue homogenously, and also at different levels. This, in turn, reduces the formation of nodules or irregularities on the skin.

First, the patient will be photographed in a standing position with marks drawn and measured so that the treatment is properly documented from start to finish. Next, a needle between 70 and 100mm long is inserted beneath the skin and using a retrograde fan technique this is then used to treat the entirety of the tissue’s surface. The procedure is almost entirely pain-free, although a small dose of 2% lidocaine is recommended to reduce any slight discomfort that may be felt.

Several sessions are required to complete the procedure, typically three, with three or four weeks between each session. This gap between each treatment is crucial in allowing the body’s normal inflammatory response to trigger and subside before more substance is applied.



Overall, patient satisfaction with fat-dissolving injections has typically been very good, although as with any form of cosmetic surgery the success of the procedure can often be perceived differently by practitioner and patient.  There are two main reasons for this: Firstly, patients tend to forget or misremember the original condition of the treated area and so are liable to underestimate the efficacy of the procedure. Secondly, practitioners naturally have access to other metrics by which to consider the result, including measurements, photographs and on some occasions ultrasound results. These metrics, coupled with the benefit of being an impartial observer can lead to these discrepancies, and so it is important that both patient and practitioner manage expectations throughout the consultation and beyond.

A thorough study of the effects and satisfaction with the experience of using lipolysis treatments highlighted which areas patients found the treatment had been most successful with. These areas were double chins, buffalo humps, and hips. Conversely, the arms and inner thighs were shown to respond less well to the treatment.

Dr.Matla Clinic
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14:21 16 Dec 19
Been to see Dr Matla three times first for a consultation where he provided me with all the information about the... procedures I was wanting was very honest and informative. Been back for Botox injections which I was very pleased with and have been back for fillers been very pleased with both procedures would highly recommend.read more
11:15 25 Nov 19
Botox treatment reduced the frequency and severity of my migraines for 10-12 weeks. Dr Matla is friendly and... professional, providing a first-rate service.read more
Jason Mohammed
Jason Mohammed
16:33 21 Oct 19
Dr Matla was very knowledgable & explained the different procedures with the expected results in a very easy to... understand manner. I went ahead with the procedures he advised & I am very happy with the results. Dr Malta’s aftercare was also excellent & would have no hesitation in recommending his services. I know I will be a returning customer.read more
Faye Ashett
Faye Ashett
22:30 17 Oct 19
Had botox for the first time. Dr Matla was very knowledge, professional and friendly. Fantastic long lasting results.... Would highly recommendread more
Karen Mead
Karen Mead
17:23 16 Oct 19
I visited Dr malta in gosforth. Firstly we chatted about the different treatments that are available. Then ran through... what would be beneficial to me. He actually talked me out of a couple of things, which I applaud as he could of made himself a lot more money. Dr malta asks you to go and think about what you've spoken about and then get back in touch.. but me being me I made my appointment for a few days later. Dr malta then done the procedure (botox) in a very professional and reassuring manner. He gave advice and creams for after care and a follow up appointment where I've attended today. At the follow up he'll take a photo of the result and ask if you're happy with it, and if not he'll offer a free top up.. I highly recommend Dr malta not only for the work but for the lovely person he is. Thank you very muchread more
Dark diva
Dark diva
17:55 14 Oct 19
Fantastic service from start to finished. Dr Matla spends a lot of time getting to know his patients so you get the... right treatment for yourself. Would highly recommend him to anyone.read more
Suzanne Crossley
Suzanne Crossley
16:29 13 Oct 19
I have been going to Dr Matla for a year now and everytime he is professional and very good at what he does. He... explains each procedure and analyses your face. Would highly recommend him.read more
elaine henderson
elaine henderson
09:03 20 Jun 18
This is the second time I have had botox done by Dr Matla and again he is very professional , explaining the process... again to ensure that I fully understood what was happening, he is very knowledgeable and continues to develop his skills in this area doing various new procedure. Therefore I will be booking in again as I am very pleased with his treatment.read more
Beverley Johnston
Beverley Johnston
20:54 16 Jun 18
Dr Matla ,is highly professional and very knowledgeable, he talked me through the whole procedure,I was very impressed... with the clinic and hygiene and will return in the near future.read more
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